1. Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages

Reddy Amala, Sundaresan Sujatha*

BioImpacts. 2021;11(1): 15-22. doi: 10.34172/bi.2021.03

PMCID: PMC7803918 PMID: 33469504 Scopus ID: 85099218046

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LPS stimulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 by binding toTLR-4. iNOS produced enormous nitric oxide (NO) that stimulated COX-2 activity and prostaglandin E2 which further induced the production of pro-inflammatory cytokines leading to inflammation. ALK-F of A. vasica could attenuate iNOS and COX-2 gene expression reducing NO production.

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